NAC Uses

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The scientific evidence presented here suggests that the use of various nutrients have the ability to reduce the risks of certain forms of cancer, cardiovascular disease, diabetes, dementia and memory loss, lung disease, joint pain, arthritis, liver disease, obesity, and metabolic function. However, the FDA has not yet determined that this scientific evidence is conclusive. Consult your physician for additional information.

Moreira PI, Harris PLR, Zhu X, Santos MS, Oliveira CR, Smith MA, and Perry G (2007) Lipoic Acid and N-acetyl Cysteine Decrease Mitochondrial-Related Oxidative Stress in Alzheimer Disease Patient Fibroblasts. Journal of Alzheimer's Disease 12:195-206.
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Atkuri KR, Mantovani JJ, Herzenberg LA, and Herzenberg LA (2007) N-Acetylcysteine ? a safe antidote for cysteine/glutathione deficiency. Current Opinion in Pharmacology 7:355?359.
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Fu AL, Dong ZH, and Sun MJ (2006) Protective effect of N-acetyl-L-cysteine on amyloid β-peptide-induced learning and memory deficits in mice. Brain Research 1109:201 ? 206.
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Stanislaus R, Gilg AG, Singh AK, and Singh I (2005) N-acetyl-L-cysteine ameliorates the inflammatory disease process in experimental autoimmune encephalomyelitis in Lewis rats. Journal of Autoimmune Diseases 2(4):1?11.
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Kalia K and Flora SJS (2005) Strategies for safe and effective therapeutic measures for chronic arsenic and lead poisoning. J Occup Health 47:1-21.
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Low WK, Sun L, Tan MGK, Chua AWC, and Wang DY (2008) L-N-Acetylcysteine protects against radiation-induced apoptosis in a cochlear cell line. Acta Oto-Laryngologica 128:440-445.
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Zell Kanter M (2006) Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning. Am J Health-Syst Pharm 63:1821-7.
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FRANCESCA TOSETTI, NICOLETTA FERRARI, SILVIO DE FLORA, AND ADRIANA ALBINI (2002) ?Angioprevention?: angiogenesis is a common and key target for cancer chemopreventive agents. FASEB J. 16, 2?14 (2002)
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Silvio De Flora, Alberto Izzotti, Francesco D'Agostini and Roumen M. Balansky (2001) Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points. Carcinogenesis vol.22 no.7 pp.999-1013, 2001
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Adriana Albini, Monica Morini, Francesco D?Agostini, Nicoletta Ferrari, Francesco Campelli, Giuseppe Arena, Douglas M. Noonan, Carlo Pesce, and Silvio De Flora (2001) Inhibition of Angiogenesis-driven Kaposi's Sarcoma Tumor Growth in Nude Mice by Oral N-Acetylcysteine CANCER RESEARCH 61, 8171?8178, November 15, 2001
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Motome Nishikawa-Ogawa, Hideki Wanibuchi, Keiichirou Morimura, Anna Kinoshita, Takayuki Nishikawa, Shuji Hayashi, Yoshihisa Yano and Shoji Fukushima (2005) N-acetylcysteine and S-methylcysteine inhibit MeIQx rat hepatocarcinogenesis in the post-initiation stage. Carcinogenesis vol.27 no.5 pp.982?988, 2005.
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Marian Valko, Dieter Leibfritz, Jan Moncola, Mark T.D. Cronin, Milan Mazura, Joshua Telser (2007) Free radicals and antioxidants in normal physiological functions and human disease. The International Journal of Biochemistry & Cell Biology 39 (2007) 44?84
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Peter Vajdovich, PhD (2008) Free Radicals and Antioxidants in Inflammatory Processes and Ischemia-Reperfusion Injury. Vet Clin Small Anim 38 (2008) 31?123
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Uwe M. Fischer, MD, Charles S. Cox, Jr, MD, Steven J. Allen, MD, Randolph H. Stewart, PhD, Uwe Mehlhorn, MD, Glen A. Laine, PhD (2003) The antioxidant N-acetylcysteine preserves myocardial function and diminishes oxidative stress after cardioplegic arrest. The Journal of Thoracic and Cardiovascular Surgery - Volume 126, Number 5 1483
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Paschalis Tossios, MD, Wilhelm Bloch, MD, Astrid Huebner, M. Reza Raji, MD, Fotini Dodos, MD, Oliver Klass, MD, Michael Suedkamp, MD, Stefan-Mario Kasper, MD, Martin Hellmich, PhD, Uwe Mehlhorn, MD (2003) N-acetylcysteine prevents reactive oxygen species?mediated myocardial stress in patients undergoing cardiac surgery: Results of a randomized, double-blind, placebo-controlled clinical trial. The Journal of Thoracic and Cardiovascular Surgery - Volume 126, Number 5 1513
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Jen Wei Chiao, Hongyan Wu, Gita Ramaswamy, C. Clifford Conaway, Fung-Lung Chung, Longgui Want and Delong Liu (2004) Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest. Carcinogenesis vol.25 no.8 pp.1403-1408, 2004
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JAGADANANDA GHOSH AND CHARLES E. MYERS (1998) Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells. Proc. Natl. Acad. Sci. USA Vol. 95, pp. 13182?13187, October 1998
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Jiaquan Zhu, MD, Rong Yin, MD, Hongtao Shao, MD, Guohua Dong, MD, Liguo Luo, MD, and Hua Jing, MD (2007) N-acetylcysteine to ameliorate acute renal injury in a rat cardiopulmonary bypass model. The Journal of Thoracic and Cardiovascular Surgery - March 2007
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