Magnesium

Pinnaclife® provides these reference articles as a courtesy to our current and future customers. They are available so that you can download, print and take articles of your choice to your next medical appointment, or share the Pinnaclife site address with your trained healthcare professional. They are not intended to imply a diagnosis or cure for any condition, illness or disease.

The scientific evidence presented here suggests that the use of various nutrients have the ability to reduce the risks of certain forms of cancer, cardiovascular disease, diabetes, dementia and memory loss, lung disease, joint pain, arthritis, liver disease, obesity, and metabolic function. However, the FDA has not yet determined that this scientific evidence is conclusive. Consult your physician for additional information.

Seeling MS. (1980) Magnesium Deficiency in the Parthogenesis of Disease. Goldwater Memorial Hospital. http://www.mgwater.com/Seelig/Magnesium-Deficiency-in-the-Pathogenesis-of-Disease/index.shtml.

Seeling M and Heggtveit A (1974) Magnesium interrelationships in ischemic heart disease: a review. The American Journal of Clinical Nutrition 27:59 - 79.
PDF (3 MB)

Shechter M, Sharir M, Labrador MJP, Forrester J, Silver B, and Merz CNB (2000) Oral Magnesium Therapy Improves Endothelial Function in Patients With Coronary Artery Disease. Circulation 102:2353 – 2358.
PDF (306 KB)

Brannan PG, Vergene-Marini P, Pak CYC, Hull AR, and Fordtran JS (1976) Magnesium Absorption in the Human Small Intestine: Results in Normal Subjects, Patients with Chronic Renal Disease, and Patients with Absorptive Hypercalciuria. J. Clin. Invest. 57:1412 – 1418.
PDF (3 MB)

Johnson S (2001) The multifaceted and widespread pathology of magnesium deficiency. Medical Hypotheses 56(2):163 – 170.
PDF (145 KB)

Shechter M, Sharir M, Labrador MJP, Forrester J, Silver B, and Merz CNB (2000) Oral Magnesium Therapy Improves Endothelial Function in Patients With Coronary Artery Disease. Circulation 102:2353-2358.
PDF (219 KB)

Larsson SC, Bergkvist L, and Wolk A (2005) Magnesium Intake in Relation to Risk of Colorectal Cancer in Women. JAMA 293(1):86-89.
PDF (159 KB)

Al-Delaimy WK, Rimm EB, Willett WC, Stampfer MJ, and Hu FB (2004) Magnesium Intake and Risk of Coronary Heart Disease among Men. American College of Nutrition 23(1):63–70.
PDF (56 KB)

Rodríguez-Morán M, and Guerrero-Romero F (2003) Oral Magnesium Supplementation Improves Insulin Sensitivity and Metabolic Control in Type 2 Diabetic Subjects: A randomized double-blind controlled trial. Diabetes Care 26:1147-1152.
PDF (113 KB)

Sales CH, and Pedrosa LDFC (2006) Magnesium and diabetes mellitus: Their relation. Clinical Nutrition 25:554-562.
PDF (143 KB)

Marx A, and Neutra RR (1997) Magnesium in Drinking Water and Ischemic Heart Disease. Epidemiol Rev 19(2):258–272.
PDF (1,597 KB)

Shechter M, Merz CNB, Rude RK, Labrador MJP, Meisel SR, Shah PK, and Kaul S (2000) Low intracellular magnesium levels promote platelet-dependent thrombosis in patients with coronary artery disease. Am Heart J 140:212–8.
PDF (177 KB)

Crosby V, Wilcock A, and Corcoran R (2000) The Safety and Efficacy of a Single Dose (500 mg or 1 g) of Intravenous Magnesium Sulfate in Neuropathic Pain Poorly Responsive to Strong Opioid Analgesics in Patients with Cancer. J Pain Symptom Manage 19:35–39.
PDF (144 KB)

Abbott RD, Ando F, Maski KH, Tung K, Rodriguez BL, Petrovitch H, Yano K, and Curb JD (2003) Dietary Magnesium Intake and the Future Risk of Coronary Heart Disease (The Honolulu Heart Program). Am J Cardiol 92:665-669.
PDF (72 KB)

Bo S, Durazzo M, Guidi S, Carello M, Sacerdote C, Silli B, Rosato R, Cassader M, Gentile L, and Pagano G (2006) Dietary magnesium and fiber intakes and inflammatory and metabolic indicators in middle-aged subjects from a population-based cohort. Am J Clin Nutr 84:1062-9.
PDF (247 KB)

King DE, Mainous III AG, Geesey ME, Woolson RF (2005) Dietary magnesium and C-reactive protein levels. Journal of the American College of Nutrition 24:166-171.
PDF (66 KB)

Tam M, Gómez S, González-Gross M, and Marcos A (2003) Possible roles of magnesium on the immune system. European Journal of Clinical Nutrition 57:1193-1197.
PDF (113 KB)

Bussiére FI, Gueux E, Rock E, Girardeau JP, Tridon A, Mazur A, and Rayssiguier Y (2002) Increased phagocytosis and production of reactive oxygen species by neutrophils during magnesium deficiency in rats and inhibition by high magnesium concentration. British Journal of Nutrition 87:107-113.
PDF (102 KB)

King DE, Mainous III AG, Geesey ME, Egan BM, and Rehman S (2006) Magnesium supplement intake and C-reactive protein levels in adults. Nutrition Research 26:193-196.
PDF (99 KB)

Song Y, Ridker PM, Manson JE, Cook NR, Buring JE, and Liu S (2005) Magnesium intake, C-reactive protein, and the prevalence of metabolic syndrome in middle-aged and older U.S. women. Diabetes Care 28:1438-1444.
PDF (138 KB)

Maier JAM, Malpuech-Brugére, Zimowska W, Rayssiguier Y, and Mazur A (2004) Low magnesium promotes endothelial cell dysfunction: implications for atherosclerosis, inflammation and thrombosis. Biochimica et Biophysica Acta 1689:13-21.
PDF (415 KB)

King JL, Miller RJ, Blue Jr. JP, O'Brien Jr. WD, and Erdman Jr. JW (2009) Inadequate dietary magnesium intake increases atherosclerotic plaque development in rabbits. Nutrition Research 29:343-349.
PDF (205 KB)

Colquhoun IW, Berg GA, el-Fiky M, Hurle A, Fell GS, and Wheatley DJ (1993) Arrhythmia prophylaxis after coronary artery surgery. A randomized controlled trial of intravenous magnesium chloride. Eur J Cardiothorac Surg 7:520-523.
PDF (981 KB)

Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PWF, and Kiel DP (1999) Potassium, magnesium, and fruit and vegetable intakes are associate with greater bone mineral density in elderly men and women. Am J Clin Nutr 69:727-36.
PDF (318 KB)

Rubenowitz E, Axelsson G, and Rylander R (1996) Magnesium in drinking water and death from acute myocardial infarction. Am J Epidemiol 143:456-62.
PDF (1,373 KB)

Paolisso G, Sgambato S, Gambardella A, Pizza G, Tesauro P, Varricchio M, and D’Onofrio F (1992) Daily magnesium supplements improve glucose handling in elderly subjects. Am J Clin Nutr 55:1161-7.
PDF (3,468 KB)

Ma J, Folsom AR, Melnick S, Eckfeldt JH, Sharrett AR, Nabulsi AA, Hutchinson RG, and Metcalf PA (1995) Associations of serum and dietary magnesium with cardiovascular disease, hypertention, diabetes, insulin, and carotid arterial wall thickness: The ARIC study. J Clin Epidemiol 48:927-940.
PDF (2,486 KB)

Gilliland FD, Berhane KT, Li YF, Kim DH, and Margolis HG (2002) Dietary magnesium, potassium, sodium, and children’s lung function. Am J Epidemiol 155:125-31.
PDF (112 KB)