Hydroxytyrosol

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The scientific evidence presented here suggests that the use of various nutrients have the ability to reduce the risks of certain forms of cancer, cardiovascular disease, diabetes, dementia and memory loss, lung disease, joint pain, arthritis, liver disease, obesity, and metabolic function. However, the FDA has not yet determined that this scientific evidence is conclusive. Consult your physician for additional information.

Liu Z, Sun L, Zhu L, Jia X, Jia H, Wang Y, Weber P, Long J, and Liu J (2007) Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction. J. Neurochem. 103:2690 – 2700.
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Furneri PM, Piperno A, Sajia A, and Bisignano G (2004) Antimycoplasmal activity of hydroxytyrosol. Antimicrobial agents and chemotherapy 48:4892-4894.
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D'Angelo S, Ingrosso D, Migliardi V, Sorrentino A, Donnarumma G, Baroni A, Masella L, Tufano MA, Zappia M, and Galletti P (2005) Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells. Free Radical Biology & Medicine 38:908-919.
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Watanabe M, Hayakawa S, Isemura M, Kumazawa S, Nakayama T, Mori C, and Kawakami T (2002) Identification of licocoumarone as an apoptosis-inducing component in licorice. Biol. Pharm. Bull 25:1388-1390.
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de la Torre R (2008) Bioavailability of olive oil phenolic compounds in humans. Inflammopharmacology 16:245-247.
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Fabiani R, Rosignoli P, De Bartolomeo A, Fuccelli R, Servili M, Montedoro GF, and Morozzi G (2008) Oxidative DNA damage is prevented by extracts of olive oil, hydroxytyrosol, and other olive phenolic compounds in human blood mononuclear cells and HL60 cells. J. Nutr. 138:1411-1416.
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Hashimoto T, Ini M, Matsuno K, Nakashima S, Tanigawa T, Yoshikawa T, and Yabe-Nishimura C (2004) An endogenous metabolite of dopamine, 3,4-dihydroxyphenylethanol, acts as a unique cytoprotective agent against oxidative stress-induced injury. Free Radical Biology & Medicine 36:555-564.
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Miro-Casas E, Covas MI, Farre M, Fito M, Ortuño J, Weinbrenner T, Roset P, and de la Torre R (2003) Hydroxytyrosol disposition in humans. Clinical Chemistry 49:945-952.
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de la Torre R, Covas MI, Pujadas MA, Fitó M, and Farré M (2006) Is dopamine behind the health benefits of red wine? Eur J Nutr 45:307-310.
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Stupans I, Stretch G, and Hayball P (2000) Olive oil phenols inhibit human hepatic microsomal activity. J. Nutr. 130:2367-2370.
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Tuck KL, Freeman MP, Hayball PJ, Stretch GL, and Stupans I (2001) The in vivo fate of hydroxytyrosol and tyrosol, antioxidant phenolic constituents of olive oil, after intravenous and oral dosing of labeled compounds to rats. J. Nutr. 131:1993-1996.
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D'Angelo S, Ingrosso D, Migliardi V, Sorrentino A, Donnarumma G, Baroni A, Masella L, Tufano MA, Zappia M, and Galletti P (2005) Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells. Free Radical Biology & Medicine 38:908-919.
PDF (459 KB)

González-Santiago M, Martin-Bautista E, Carrero JJ, Fonollá J, Baró L, Bartolomé MV, Gil-Loyzaga P, and López-Huertas E (2006) One-month administration of hydroxytyrosol, a phenolic antioxidant present in olive oil, to hyperlipemic rabbits improves blood lipid profile, antioxidant status and reduces atherosclerosis development. Atherosclerosis 188:35-42.
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Visioli F, Galli C, Grande S, Colonnelli K, Patelli C, Galli G, and Caruso D (2003) Hydroxytyrosol excretion differs between rats and humans and depends on the vehicle of administration. J. Nutr. 133:2612-2615.
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Visioli F, Galli C, Plasmati E, Viappiani S, Hernandez A, Colombo C, and Sala A (2000) Olive phenol hydroxytyrosol prevents passive smoking-induced oxidative stress. Circulation 102:2169-2171.
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D’Angelo, Manna C, Migliardi V, Mazzoni O, Morrica P, Capasso G, Pontoni G, Galletti P, and Zappia V (2001) Pharmacokinetics and metabolism of hydroxytyrosol, a natural antioxidant from olive oil. DMD 29:1492-1498.
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Moreno JJ, Carbonell T, Sánchez T, Miret S, and Mitjavila T (2001) Olive oil decreases both oxidative stress and the production of arachidonic acid metabolites by the prostaglandin G/H synthase pathway in rat macrophages.
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Deiana M, Incani A, Rosa A, Corona G, Atzeri A, Loru D, Melis MP, and Dessi A (2008) Protective effect of hydroxytyrosol and its metabolie homovanillic alcohol on H2O2 induced lipid peroxidation in renal tubular epithelial cells. Food and Chemical Toxicology 46:2984-2990.
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Covas MI, Ruiz-Gutiérrez V, de la Torre R, Kafatos A, Lameula-Raventós RM, Osada J, Owen RW, and Visioli F (2006) Minor components of olive oil: Evidence to date of health benefits in humans. Nutrition Reviews 64:S20-S30.
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Budiyanto A, Ahmed NU, Wu A, Bito T, Nikaido O, Osawa T, Ueda M, and Ichihashi M (2000) Protective effect of topically applied olive oil against photocarcinogenesis following UVB exposure of mice. Carcinogenesis 21:2085-2090.
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Manna C, Galletti P, Maisto G, Cucciolla V, D’Angelo S, and Zappia V (2000) Transport mechanism and metabolism of olive oil hydroxytyrosol in Caco-2 cells. FEBS Letters 470:341-344.
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