Diabetes

Pinnaclife® provides these reference articles as a courtesy to our current and future customers. They are available so that you can download, print and take articles of your choice to your next medical appointment, or share the Pinnaclife site address with your trained healthcare professional. They are not intended to imply a diagnosis or cure for any condition, illness or disease.

The scientific evidence presented here suggests that the use of various nutrients have the ability to reduce the risks of certain forms of cancer, cardiovascular disease, diabetes, dementia and memory loss, lung disease, joint pain, arthritis, liver disease, obesity, and metabolic function. However, the FDA has not yet determined that this scientific evidence is conclusive. Consult your physician for additional information.

Hamden K, Allouche N, Damak M, and Elfeki A (2009) and antioxidant effects of phenolic extracts and purified hydroxytyrosol from olive mill waste in vitro and in rats. Chemico-Biological Interactions 180:421-432.
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Ruhe RC, and McDonald RB (2001) Use of Antioxidant Nutrients in the Prevention and Treatment of Type 2 Diabetes. Journal of the American College of Nutrition 20(5):363S-369S.
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Nakaya Y, Minami A, Harada N, Sakamoto S, Niwa Y, and Ohnaka M (2000) Taurine improves insulin sensitivity in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous type 2 diabetes. Am J Clin Nutr 71:54-58.
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Li F, Obrosova IG, Abatan O, Tian D, Larkin D, Stuenkel EL, and Stevens MJ (2005) Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats. Am J Physiol Endocrinol Metab 288:29-36.
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Wu QD, Wang JH, Fennessy F, Remond HP, and Bouchier-Hayes D (1999) Taurine prevents high-glucose-induced human vascular endothelial cell apoptosis. Am J Physiol Cell Physiol 277:1229-1238.
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Franconi F, Bennardini F, Mattana A, Miceli M, Ciuti M, Mian M, Gironi A, Anichini R, and Seghieri G (1995) taurine are reduced in subjects with insulin-dependent diabetes mellitus: effects of taurine supplementation. Am J Physiol Cell Physiol 277:1229-1238.
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Ozkilic AC, Cengiz M, Oxaydin A, Cobanoglu A, and Kanigur G (2006) The Role of N-acetylcysteine Treatment on Anti-oxidative Status in Patients with Type II Diabetes Mellitus. Journal of Basic & Clinical Physiology & Pharmacology 17(4):245-254.
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Xia Z, Kuo K, Nagareddy PR, Wang F, Guo Z, Guo T, Jiang J, McNeill JH (2007) N-acetylcysteine attenuates PKCβ₂ overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats. Cardiovascular Research 73:770-782.
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Odetti P, Pesce C, Traverso N, Menini S, Maineri EP, Cosso L, Valentini S, Patriarca S, Cottalasso D, Marinari U, and Pronzato MA (2003) Comparative Trail of N-Acetyl-Cysteine, Taurine, and Oxerutin on Skin and Kidney Damage in Long-Term Experimental Diabetes. Diabetes 52:499-505.
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Ho E, Gouman C, and Bray T (1999) Supplementation of N-acetylcysteine inhibits NFκB activation and protects against alloxan-induced diabetes in CD-1 mice. FASEB J. 13, 1845-1854
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Montonen J, Knekt P, Arvinen RJ, Reunanen A (2004)Dietary Antioxidant Intake and Risk of Type 2 Diabetes Diabetes Care 27:362-366
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Kaneto H, Kajimoto Y, Miyagawa J, Matsuoka T, Fujitani Y, Umayahara Y, Hanafusa T, Matsuzawa Y, Yamasaki Y, and Hori M (1999) Beneficial Effects of Antioxidants in Diabetes Possible Protection of Pancreatic β-Cells Against Glucose Toxicity Diabetes 48:2398-2406
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Tosetti F, Ferrari N, Flora SD, Albini A (2002) 'Angioprevention': angiogenesis is a common and key target for cancer chemopreventive agents FASEB J. 16, 2-14
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Albini A, Morini M, D'Agostini F, Ferrari N, Campelli F, Arena G, Noonan DM, Pesce C, and Flora SD (2001) Inhibition of Angiogenesis-driven Kaposi's Sarcoma Tumor Growth in Nude Mice by Oral N-Acetylcysteine1 Cancer Research 61,8171-8178
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Robertson PR, Harmon J, Tran PO, Tanaka Y, and Takahashi H (2003) Glucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection Diabetes 52: 581-587
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Valko M, Leibfritz D, Moncola J, Cronin MTD, Mazura M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease The International Journal of Biochemistry &; Cell Biology 39:44-84
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Fiordaliso F, Bianchi R, Staszewsky L, Cuccovillo I, Doni M, Laragione T, Salio M, Savino C, Melucci S, Santangelo F, Scanziani E, Masson S, Ghezzi P, Latini R (2004) Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats Journal of Molecular and Cellular Cardiology 37:959-968
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Vajdovich P (2008) Free Radicals and Antioxidants in Inflammatory Processes and Ischemia-Reperfusion Injury Vet Clin Small Anim 38:31-123
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Fischer UM, Cox CS Jr, Allen SJ, Stewart RH, Mehlhorn U, Laine GA (2003) The antioxidant N-acetylcysteine preserves myocardial function and diminishes oxidative stress after cardioplegic arrest The Journal of Thoracic and Cardiovascular Surgery - Volume 126, Number 5 1483
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Tossios P, Bloch W, Huebnera A, Raji MR, Dodos F, Klass O, Suedkamp M, Kasper SM, Hellmich M, Mehlhorn U (2003) N-acetylcysteine prevents reactive oxygen species-mediated myocardial stress in patients undergoing cardiac surgery: Results of a randomized, double-blind, placebo-controlled clinical trial The Journal of Thoracic and Cardiovascular Surgery - Volume 126, Number 5 1513
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Haber CA, Lam TKT, Yu Z, Gupta N, Goh T, Bogdanovic E, Giacca A, and Fantus GI (2003) N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress Am J Physiol Endocrinol Metab 285: E744-E753
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Tanaka Y, Gleason CE, Tran POT, Harmon JSS, Robertson RP (1999) Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants Proc. Natl. Acad. Sci. USA Vol. 96, pp. 10857-10862
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Zhu J, Yin R, Shao H, Dong G, Luo L, Jing H (2007) N-acetylcysteine to ameliorate acute renal injury in a rat cardiopulmonary bypass model The Journal of Thoracic and Cardiovascular Surgery
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Oliveras-López MJ, Berná G, Carneiro EM, López-Garcia de la Serrana H, Martin F, and López MC (2008) An Extra-Virgin Olive Oil Rich in Polyphenolic Compounds Has Antioxidant Effects in Mice. J. Nutr. 138:1074-1078.
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Tentolouris N, Arapostathi C, Perrea D, Kyriaki D, Revenas C, Katsilambros N (2008) Differential effects of two different isoenergetic meals one rich in saturated and one rich in monounsaturated fat on endothelial function in subjects with type 2 diabetes mellitus. American Diabetes Association, Inc.
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Assy N, Nassar F, Nasser G, and Grosovski M (2009) Olive oil consumption and non-alcoholic fatty liver disease. World J Gastroenterol 15:1809-1815.
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Bustamante J, Lodge JK, Marcocci L, Tritschler HJ, Packer L, and Brihn BH (1997) *α-Lipoic Acid In Liver Metabolism And Disease. Free Radical Biology & Medicine, Vol. 24, No. 6, pp. 1023–1039, 1998
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Midaoui AE, Champlain JD (2002) Prevention of Hypertension, Insulin Resistance, and Oxidative Stress by α-Lipoic Acid. Hypertension. 2002;39:303-307.
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